WebSep 21, 2016 · Bruzzi et al 1 have evaluated objective response rate (ORR) as a potential surrogate end point for survival in metastatic breast cancer patients. Throughout oncology, many biomarkers have been evaluated. Examples include direct measures of the tumor burden process, such as ORR or progression-free survival (PFS), or inherently less … WebA descriptive analysis of the CodeBreaK 100 study evaluating the efficacy of LUMAKRAS in patients with locally advanced or metastatic KRAS G12C–mutated NSCLC from across the globe. The study included 174 patients from the Phase 1 (n=48) and Phase 2 (n=126) portions. Efficacy outcomes included objective response rate as evaluated by BICR ...
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WebSep 20, 2024 · This group of patients had locally advanced or metastatic disease and had not received prior systemic therapy. For the 147 people in the trial, objective response rate was 47.6%, which included some complete responses, and the disease control rate was 79.3% during a median follow up of 8.2 months. WebFeb 24, 2024 · The tumor objective response rate (ORR) is an important parameter to demonstrate the efficacy of a treatment in oncology. ... is widely accepted by regulatory … greek orthodox west perth
Frontiers Efficacy and safety of PD-1/PD-L1 inhibitor combined …
WebNov 24, 2024 · Overall, 1% patients with advanced solid tumors can expect to achieve some response even in absence of treatment. However, complete regression without treatment is extremely rare, almost zero percent. This information will be helpful to patients in their decisions, as well as regulators in evaluating cancer drugs’ efficacy based on response … WebMay 12, 2024 · The primary endpoint was confirmed objective response rate as determined by blinded independent central review (BICR). 91 patients were enrolled from 40 sites globally, 89 of whom received treatment. Key demographics and disease characteristics are consistent with real-life practice (median age 75 years, 12% Eastern … WebSecondary outcomes estimated using OR were disease objective response rate (DORR) and incidence of adverse events. Results: Four RCTs with a total of 3,013 patients researching the efficacy of immunotherapy plus chemotherapy versus chemotherapy alone on gastrointestinal cancer were included in this meta-analysis. greek orthodox youth of america