Circhif1a

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August undefined, 2024

WebJun 12, 2024 · Candidate circHIF1A (circ_0032138) was screened out and it was confirmed that circHIF1A was up-regulated in the exosomes from hypoxic CAFs and their … WebcircHIF1A-miRNA-149-5p Interaction with NFIB: Promotion of cell proliferation and metastasis: 0.897: Chen 2024 : Table 2. Summary of the prognostic and predictive role of blood circulating ncRNAs for TNBC (AUC—area under the ROC, CR—complete response, HR—hazard ratio, OR—odds ratio, OS—overall survival, PD—progressive disease, PR ...

HIF1A Gene - GeneCards HIF1A Protein HIF1A Antibody

WebThe discovery may establish circHIF1A as a therapeutic target in breast cancer treatment. Kaihua Yang et al . revealed that circEIF3K/miR-214/PD-L1 signaling axis was involved in the progression of colorectal cancer. 26 Similarly, circEIF3K was confirmed to be produced by CFAs and delivered to tumor cells via exosomes, indicating a novel ... WebHIF1A. Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 ( HIF-1) that is encoded by the HIF1A gene. [5] [6] [7] The Nobel Prize in … how to request a new medicare card

Emerging Roles of CircRNAs in Tumor Microenvironment

WebcircHIF1A was selectively upregulated in hypoxic breast cancer exosomes specifically.25 Additionally, circHIF1A counteracting miR-580-5p-mediated inhibition on CD44 via sponging miR-580-5p was found to be the mechanism via which CAFs modulated the stemness of cancer cells. The discovery may establish circHIF1A WebAug 29, 2024 · We previously reported that circHIF1A could facilitate TNBC proliferation and metastasis by increasing the expression level of NFIB . However, the functions and underlying mechanisms of circRNAs in regulating chemoresistance of TNBC are largely unknown. Therefore, identifying circRNAs that possess regulatory roles in … WebChen, T., Wang, X., Li, C., Zhang, H., Liu, Y., Han, D., … Yang, Q. (2024). CircHIF1A regulated by FUS accelerates triple-negative breast cancer progression by ... how to request a new ebt card in pa

EIF4A3-mediated circPRKCI expression promotes triple-negative

Circular RNAs: Emerging regulators of glucose metabolism in cancer

WebMar 21, 2024 · HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF1A include Retinal Ischemia and Enchondromatosis, … WebMar 2, 2024 · CircHIF1A regulated by FUS accelerates triple-negative breast cancer progression by modulating NFIB expression and translocation 13 March 2024 Tong Chen, Xiaolong Wang, … how to request a new nhs smart cardWebJun 14, 2024 · [Cell Death Discovery] Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated … how to request a new probation officer

"WebRegulation of HIF-1α stability can also be mediated by an oxygen-independent pathway. In the cytoplasm, HIF-1α is bound to heat-shock protein 90 (Hsp90), leading to enhanced … " - Circhif1a

Circhif1a

WebMechanistically, circHIF1A modulated the expression and translocation of NFIB through posttranscriptional and posttranslational modifications, resulting in the activation of the … First, we constructed a circHIF1A overexpression plasmid and designed two small interfering RNAs (siRNAs) targeting the splicing junction of circHIF1A. CircHIF1A overexpression and knockdown efficiencies in TNBC were validated by qRT-PCR (Supplementary Fig. 2A). The expression levels of linear HIF1A … See more Fused in sarcoma (FUS) belongs to the FET family of ubiquitously expressed RNA-binding proteins involved in multiple stages of RNA processing [30, 31]. Recently, FUS was … See more Interestingly, we found that ectopic expression of NFIB could increase circHIF1A expression, while NFIB knockdown led to … See more Because the potential roles of FUS in TNBC progression are largely unknown, we conducted functional experiments with FUS overexpression … See more

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WebJul 28, 2024 · In another study, exosomal circHIF1A significantly promoted triple negative breast cancer growth. An exosomal circHIF1A/NFIB/FUS feedback loop was validated by Chen et al., as exosomal circHIF1A modulated the expression and translocation of NFIB through post-transcriptional and post-translational modification. WebIn BC, sEVs derived from hypoxic CAFs show higher circHIF1A levels than normoxic CAFs. circHIF1A acts as a sponge for miR-580-5p, lowering its levels, whilst miR-580-5p targets the CD44 molecule mRNA, decreasing CD44 expression . Protein transfer from CAFs to cancer cells through sEVs also plays an essential role in tumorigenesis. Breast ...

WebThe breast cancer cells were used to establish the models in BALB/C nude mice and hypoxia exosomes with circHIF1A shRNA or the controls were injected into the nude … WebJun 3, 2024 · Posttranscriptional tRNA modifications are essential for proper gene expression, and defects in the enzymes that perform tRNA modifications ar ...

WebMar 10, 2024 · Epithelial-to-mesenchymal transition (EMT) is a dynamic program of cell plasticity aberrantly reactivated in cancer. The crosstalk between tumor cells and the tumoral microenvironment (TME) has a pivotal importance for the induction of the EMT and the progression toward a malignant phenotype. Notably, exosomes are key mediators of this … WebJan 4, 2024 · Zhan et al. have found that circHIF1A from CAF-derived exosomes can be taken up by breast cancer cells and thus plays an important role in the regulation of cancer stem cell properties by sponging miR-580-5p and therefore changing CD44 expression. In addition, exosomal circsl7a6 secreted by CAFs is reported to promote the initiation of CRC.

WebJul 15, 2024 · The RNA-binding protein FUS regulates the biogenesis of circHIF1A by interacting with flanking introns, and significantly promotes TNBC growth and metastasis . 4. Cis-Regulatory Elements. In addition to trans-acting factors that regulate circRNA biogenesis, many cis-regulatory elements can also influence the cyclization of RNA. In …

WebApr 15, 2024 · CircHIF1A promoted TNBC progression both in vitro and in vivo A (left) Cluster heat map showed the differentially expressed genes in MDA-MB-231 cells with circHIF1A overexpression and control cells. how to request a new ebt cardWebAug 20, 2024 · The RNA-binding protein FUS regulates the biogenesis of circHIF1A by interacting with flanking introns, and significantly promotes TNBC growth and metastasis . Go to: 4. Cis-Regulatory Elements. In addition to trans-acting factors that regulate circRNA biogenesis, many cis-regulatory elements can also influence the cyclization of RNA. In ... how to request a new medicaid cardWebJun 14, 2024 · [Cell Death Discovery] Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated … north carolina bank owned homesWebMini-Circuits. Manufacturer Product Number. PHA-1+. Description. IC RF AMP CATV 50MHZ-6GHZ SOT89. Manufacturer Standard Lead Time. 10 Weeks. Detailed … north carolina bank owned homes for saleWebMay 10, 2024 · So, circHIF1A could be a novel biomarker for the diagnosis and therapeutic target of TNBC . Epithelial-mesenchymal transformation (EMT) is a fundamental level in TNBC metastasis. Epithelial-mesenchymal transformation (EMT) is a fundamental level in TNBC metastasis. north carolina bankruptcy exemption lawsWebTong Chen et al. (2024) revealed that circHIF1A, which was upregulated in the plasma of BC patients, could be selectively loaded into exosomes secreted by BC cells. CircHIF1A promoted TNBC growth and metastasis by regulating NFIB expression and subcellular location and was involved in the circHIF1A/NFIB/FUS positive feedback loop. how to request a new discover cardWebJun 12, 2024 · CircHIF1A may act as a target molecule of breast cancer therapy. Hypoxia is a common phenomenon in solid tumors. The roles of exosomes from hypoxic breast … north carolina bankruptcy