Cisplatin target

Author: drtf

August undefined, 2024

WebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy. Solutions are best fresh-prepared. WebNov 29, 2024 · Thus, pemetrexed and cisplatin target reciprocal lung cancer subpopulations, which could explain the increased efficacy of the combination therapy in …

Targeted therapy for cisplatin‐resistant lung cancer via …

WebJul 28, 2024 · Many of the most commonly prescribed chemotherapeutics, including platinum-based compounds such as cisplatin, target the characteristic genomic instability of tumors by directly damaging the … The compound cis-[Pt(NH3)2Cl2] was first described by Italian chemist Michele Peyrone in 1845, and known for a long time as Peyrone's salt. The structure was deduced by Alfred Werner in 1893. In 1965, Barnett Rosenberg, Van Camp et al. of Michigan State University discovered that electrolysis of platinum electrodes generated a soluble platinum complex which inhibited binary fission in Escherichia coli (E. coli) bacteria. Although bacterial cell growth continued, cell division … chromosome 15 abnormalities

A Combined Systemic Strategy for Overcoming Cisplatin

WebNCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. WebJun 13, 2005 · Cisplatin is a platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors. Brand Names. Platinol. … WebApr 11, 2024 · Cisplatin has gained clinical success and has been proven to target various kinds of cancers, namely, lung, head and neck, bladder, cervical, and ovarian cancers [ 2 ]. Upon cisplatin entry to the cell, it becomes activated by hydrolysis. chromosome 14 inversion

Targeted therapy for cisplatin‐resistant lung cancer via …

Cisplatin in cancer therapy: molecular mechanisms of action

WebApr 12, 2012 · Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions … WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … chromosome 14 genetic testingWebThe drug can be administered to hemodialysis (HD) patients to achieve an AUC of 4–6 such that carboplatin dose (mg)=Target AUCx25. The drug is not avidly protein bound shortly after administration, and approximately 70% is cleared by HD if performed within several hours after in- fusion (15). chromosome 15 function

"WebJan 26, 2024 · They are looking at the cellular mechanism by which cisplatin is taken up by the cells of the stria vascularis to find ways to block uptake, as well as identify drugs that … " - Cisplatin target

Cisplatin target

Review of the Comparative Pharmacology and Clinical Activity of ...

WebCisplatin (DDP) is a common therapeutic option for non‐small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. ... Aptamer‐targeted nano‐zinc carriers were loaded with USP14 siRNA to target DDP ... WebJan 10, 2024 · Characterization of cisplatin-loaded chitosan nanoparticles and rituximab-linked surfaces as target-specific injectable nano-formulations for combating cancer Characterization of cisplatin-loaded chitosan nanoparticles and rituximab-linked surfaces as target-specific injectable nano-formulations for combating cancer Authors

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WebCisplatin is a member of the alkylating agents drug class and is commonly used for Anal Cancer, Bladder Cancer, Blood Cell Transplantation, and others. ... , Target, WalMart … WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often …

WebApr 13, 2024 · Bonn researchers uncover contribution of protein degradation processes to cisplatin resistance in germ cell tumors: Cisplatin is used successfully in the … Web2 days ago · Testicular cancer, also known as testicular germ cell tumors (TGCT), is the most common type of cancer in young men. When treated with cisplatin, the tumor cells …

WebApr 13, 2024 · Testicular cancer, also known as testicular germ cell tumors (TGCT), is the most common type of cancer in young men. When treated with cisplatin, the tumor cells stop growing and die. This is because the cytostatic drug causes damage to DNA, the carrier of genetic information, thus stopping the cell cycle. "The alarm signal is sent … WebCisplatin is a chemotherapy drug. You might have it as a treatment for a number of different types of cancer. You might have cisplatin on its own or in combination with other cancer …

WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying …

WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes … chromosome 15q24 microdeletion syndromeWebJul 1, 2024 · The main target of cisplatin is genomic DNA (gDNA) but a very little amount (∼1%) of intercellular cisplatin is generally bound to gDNA [58]. Several proteins like … chromosome 16p11.2 deletion syndrome icd 10WebThe cellular uptake of cisplatin and its targets. Reprinted with permission. 1. As seen in Figure 1, once inside the cell, cisplatin has a number of possible targets: DNA; RNA; … chromosome 15 tay sachsWebJan 13, 2011 · Cisplatin is one of the most effective chemotherapeutic agents against many forms of cancer including testicular, bladder, head and neck, ovarian, breast, lung, … chromosome 16 inversionWebNov 11, 2008 · The ability of cis-diamminedichloroplatinum(II), cisplatin (9, 10), to inhibit the growth of cancer cells by interfering with transcription and other DNA-mediated cellular functions has been elucidated over the past 30 years.Cisplatin is highly effective against several forms of cancer, most notably testicular tumors, and it is also commonly used to … chromosome 15 genesWebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. ... Aptamer-targeted nano-zinc carriers were loaded with USP14 siRNA to target DDP ... chromosome 16p duplicationWebCisplatin is a chemotherapeutic drug that has been used in the treatment of various types of human cancers such as ovarian, lung, head and neck, testicular and bladder. Cisplatin … chromosome 17 abnormalities