Ctcf and ctcfl in cancer

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August undefined, 2024

WebFeb 16, 2024 · CTCF overexpression has been identified in breast cancer , cervical cancer , ovarian cancer , and hepatocellular carcinoma . Some mutations are related to tumors ( 15 ). In particular, hotspot binding site mutations occur at quite a high frequency (25%) in GC, and these mutations are associated with alterations in gene expression ( 16 ). WebAug 31, 2016 · A common aberration in cancer is the activation of germline-specific proteins. The DNA-binding proteins among them could generate novel chromatin states, not found in normal cells. The germline-specific transcription factor BORIS/CTCFL, a paralog of chromatin architecture protein CTCF, is often erroneously activated in cancers and …

CTCFL regulates the PI3K-Akt pathway and it is a target for

WebFeb 7, 2024 · The oncogene CTCFL (BORIS), the paralog of CTCF, is a transcriptional factor highly expressed in ovarian cancer (but in rarely any other tissue in females) with cancer-specific characteristics and ... WebCTCFL; Zinc finger protein CTCF-T; cancer/testis antigen 27; dJ579F20.2; Description CTCFL, a testis-specific DNA binding protein containing 11 C2H2-type zinc fingers, … share entertainment

CTCF and CTCFL in cancer. - Abstract - Europe PMC

WebCCCTC-binding factor ( CTCF ), an 11- zinc finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive … WebNational Center for Biotechnology Information shareenum

The Bromodomain Containing 8 (BRD8) Transcriptional Network in …

BORIS: a key regulator of cancer stemness - Cancer Cell …

WebCTCFL is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes. ... BORIS like protein; BORIS-like protein; Brother of the regulator of imprinted sites; Cancer/testis antigen 27; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein)-like; CCCTC-binding factor like; CT27; CTCF paralog; CTCF T; … WebMar 29, 2024 · CTCF and CTCFL in cancer. Dynamic regulation of CTCF stability and sub-nuclear localization in response to stress. Defining the relative and combined contribution … share entitlementWebApr 18, 2024 · In cancer, CTCF binding is disrupted through various mechanisms, such as DNA copy number alterations spanning domain boundaries 13, microdeletions within CBSs 13, and hypermethylation of CBSs 14 ... share entire computer over network

"WebApr 10, 2024 · Pan-cancer bioinformatics analysis showed that the expression of DTL was correlated with the prognosis, immunotherapy, and clinical indexes in various cancers. ... NRF1, E2F4, STA T3, CTCF, CTCFL ... " - Ctcf and ctcfl in cancer

Ctcf and ctcfl in cancer

(PDF) Pan-cancer analysis and experimental validation of DTL as a ...

WebThe LOF of CTCF or cohesin in cancer may cause activation of oncogenes through altering chromatin loops (Fig. 4). CTCF is frequently mutated in endometrial carcinoma, head … WebApr 4, 2024 · CTCF provided by HGNC Official Full Name CCCTC-binding factor provided by HGNC Primary source HGNC:HGNC:13723 ... LncRNA PCGEM1 promotes colorectal cancer cell proliferation and migration in positive feedback loop through PCGEM1/miR-433-3p/CTCF axis. ... CTCFL paralog. NCBI Reference Sequences (RefSeq) Go to the top of …

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WebResearch to identify CTCFL as a biomarker for specific cancer types and for therapeutical approaches has been followed up . With the advent of next-generation-sequencing many advances in the field of DNA binding factors have been made. ... CTCF/CTCFL co-bound and CTCF or CTCFL stand-alone sites) and the average CTCF site as reference were ... WebCancer; Cell Biology; Stem Cells & Development; Metabolic & Cardiovascular Disease; ... 我们为您找到 ctcf 的 1 个相关产品结果。 ... Synonyms: CTCFL;BORIS;CT27;CTCF-T;HMGB1L1;dJ579F20.2. Type: Rabbit Polyclonal Antibody (1) 加入对比（最多5 ...

WebApr 1, 2024 · In this regard, BORIS (CTCFL), a CTCF paralog, is a promising cancer biomarker that is overexpressed and controls transcription in several cancer types, … WebCancer remains the main cause of human death worldwide, and most cancers still lack effective prevention and treatment means ... that DTL interacted with arsenic trioxide, aflatoxin b1, MLN7243 and palmitic acid. In addition, NRF1, E2F4, STAT3, CTCF, CTCFL and E2F1 were predicted to be the interacting targets. Hsa-miR-330-3p, hsa-miR ...

WebNov 15, 2013 · Estrogens play a key role in breast cancer, with 60-70% of the cases expressing estrogen receptors (ERs), which are encoded by the ESR1 gene. CTCFL, a paralogue of the chromatin organizer CTCF, is a potential biomarker of breast cancer, but its expression in this disease is currently controversial. A positive correlation has been … WebJun 23, 2024 · The past and present efforts to combine CTCF studies with CTCFL/BORIS research are designed to emphasize Normal and …

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WebMar 3, 2024 · An expanding literature describes a cancer-associated role for BRD8 (reviewed in (Fujisawa and Filippakopoulos, ... Since BRD8 is not predicted to bind directly to DNA, an association with CTCF/CTCFL could be an effective route to achieving chromatin proximity (Pena-Hernandez, Marques, Hilmi et al., 2015). To further explore … shareen\u0027s cuisineWebMar 30, 2024 · Here, we show that MYC reshapes the chromatin architecture of prostate cancer (PCa) cells through interacting with CTCF protein. By defining H3K27ac, AR and CTCF HiChIP profiles and CRISPR ... share entryWebApr 13, 2024 · MYC reshapes CTCF-mediated chromatin architecture in prostate cancer. April 13, 2024. MYC is a well characterized oncogenic transcription factor in prostate … pooping explosiveWebAug 4, 2024 · Pancreatic cancer’s poor prognosis is caused by distal metastasis, which is associated with epigenetic changes. However, the role of the 3D epigenome in pancreatic cancer biology, especially its metastasis, remains unclear. ... Notably, all sets of NDRs had CTCF and CTCFL motifs, which was consistent with the fact that CTCF is a vital ... pooping everywhereWebSmits et al. report that TLX3 chromosomal translocations in T cell acute lymphoblastic leukemia patients recurrently include intervening CTCF-binding sites in the breakpoint area. Pressure to acquire inactivating aberrations in CTCF abrogate consequential enhancer insulation that promotes TLX3 promoter to BCL11B enhancer looping boosts higher … pooping fanficWebMay 11, 2024 · Ubiquitously expressed CTCF is involved in numerous cellular functions, such as organizing chromatin into TAD structures. In contrast, its paralog, CTCFL, is … share environment power platformWebJun 15, 2005 · Abstract. CTCF is a candidate tumor suppressor gene encoding a multifunctional transcription factor. Surprisingly for a tumor suppressor, the levels of CTCF in breast cancer cell lines and tumors were found elevated compared with breast cell lines with finite life span and normal breast tissues. In this study, we aimed to investigate the … pooping every time you eat