WebFerritin heavy chain 1. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. FTH1 (FHC, FTH, FTHL6, PIG15, PLIF) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). Read more. Cancer-related genes. Candidate cardiovascular disease genes. WebFeb 1, 2024 · This identified four genes as significant: FTH1, RCC2, ABHD17B, and IRAK1. Through survival analysis, FTH1 was identified as a key gene associated with AML prognosis. We verified the proliferative and regulatory effects of ferroptosis on MOLM-13 and THP-1 cells using Liproxstatin-1 and Erastin respectively by CCK-8 and flow …
Subcellular location of FTH1 - The Human Protein Atlas
WebApr 3, 2024 · To further examine whether iron overload is caused by ferritinophagy, we assessed the effect of Sch B on the expression of FTH1 in cultured LX2 cells. The protein expression of FTH1 was increased by Sch B (Figure 4(e)). Additionally, Sch B promoted the binding of NCOA4 to FTH1 in vitro (Figure 4(f)). Collectively, these data suggested that … WebDec 21, 2024 · Within expectation, a simultaneous degradation of NCOA4 and FTH1 was observed in cisplatin-treated BUMPT cells, which was partially restored by myo-inositol treatment (Figure 3O, lanes 1 and 2). All in all, these in vitro data indicated that myo -inositol down-regulates the expression profile of NOX4 to decelerate ferroptosis in cisplatin ... rainbow kitten surprise setlist
The NSUN5-FTH1/FTL pathway mediates ferroptosis in …
WebNov 23, 2024 · The cell migration by wound healing experiments did not show an apparent stable difference between FTH1-OE cells and vector control cells (Fig. S2). However, a quantitative live cell imaging system of both Caco-2 and SW480 cells showed that cells proliferated faster in the FTH1-OE group (Fig. 4b). In addition, EdU assays suggested … WebApr 20, 2024 · Up to now, FTH1 is generally considered to have antioxidant properties that could protect cells from reactive oxygen species (ROS) due to its ferroxidase activity which could catalyse the conversion of Fe 2+ into Fe 3+. 17, 20 Meanwhile, NF‐κB‐mediated FTH1 upregulation is thought to protect cells from apoptosis. 35, 40 However, our ... WebMar 24, 2024 · Downregulation of miR-21-5p suppressed the level of MELK and the progression of HCC. MELK regulated the AKT/mTOR signaling pathway, causing changes in the levels of GPX4, GSH, FTH1, xCT, heme oxygenase 1(HO-1), reactive oxygen species, and Fe 2+ to regulate the ferroptosis of hepatoma cells. Erastin, an inducer of … cvte mandarin model