Web18 dec. 2014 · Although all p53−/−;Lck-Cre;Bcl-xfl/+ mice developed cancer, the proportion of mice exhibiting thymic lymphoma was reduced compared with p53−/−;Lck-Cre mice ( Figure 1B ). This reduction in thymic lymphoma incidence was compensated by an increase in other tumors (eg, splenomegaly and sarcoma). WebThe Ctcf f/fl mice 7 were provided by Rudi Hendriks (Erasmus Medical Center Rotterdam). The Lck-cre mice 95 were purchased from Taconic (Rensselaer, NY). Further details are listed in the key resources table. The mice were bred and/or maintained at the animal care facilities of the Erasmus Medical Center Rotterdam and the Hubrecht Institute.
Glutamate Receptor Interacting Protein 1 Regulates CD4+ CTLA-4 ...
WebAlthough these investigators observed an improved imiquimod-induced psoriasiform phenotype with keratinocyte-specific ablation of Hmgb1, knockout of the Hmgb1 gene in dendritic cells (using Itgax promoter-driven Cre in Hmgb1 floxed mice), myeloid cells (Lyz2 promoter-driven Cre) or T cells (Lck promoter-driven Cre) produced no significant effect. … WebGenetics negative control • use littermates from BRCA1+/- cross Jeong J, Jo A, Park P, Lee H, Lee H-O. 2015. Brca2 Deficiency Leads to T Cell Loss and Immune Dysfunction. Mol Cells. 2015 Mar 31; 38(3): 251–258. Fig 3: Loss of naïve T cells in [Brca2F11/F11; Lck-Cre] mice. Splenic T cells were isolated from 4–8-week-old or 36–42-week-old WT, … meiyouservice outlook.com
T细胞特异Cre转基因小鼠-
WebLa Bibliothèque Virtuelle de Santé est une collection de sources d'information scientifiques et techniques en santé, organisée et stockée dans un format électronique dans les pays de la Région d'Amérique Latine et des Caraïbes, universellement accessible sur Internet et compatible avec les bases de données internationales. WebMortality in the GR(lck-Cre) mice was associated with immunopathology and hyperactive Th1 cell function as revealed by enhanced IFN-gamma and TNF production in vivo. Unexpectedly, these CD4(+) T lymphocytes also overexpressed IL-10. Importantly, CD4(+) T cell depletion in wild-type or GR(lck-Cre) mice led to ablation of the GC response to ... WebDescription. The ATP competitive CDK inhibitors (CDK1/cyclinB, CDK2/cyclinA, CDK2/cyclinE and CDK5/p25 have IC50 values of 0.4, 0.68, 7.5, and 0.85 µM, respectively). It also inhibits GSK-3β and LCK (IC50 values of 0.23 and 0.47 µM, respectively), and reduces activity against other kinases (c-src, casein kinase 2, ERK1 and ERK2 have … napalabourwarranty.com